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Emphasis should be placed on clarifying the regulatory pathways of immune-metabolic axes mediated by dual-regulating molecules through hub molecules such as mTOR and HIF-1, and expanding mechanistic exploration in emerging fields such as the gut-lung axis and neuro-immune-metabolic crosstalk (Harbaum et al., 2021

Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA

Acknowledgements We thank the Swanson Biotechnology Center at the Koch Institute, including the Flow Cytometry, Histology, and ES Cell and Transgenics core facilities

We propose that restoring cellular voltage, reducing tissue hypoxia, and mechanically forcing detoxification pathways is the essential prerequisite for biochemical interventions to be effective