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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

Characterization of subepithelial interstitial cells in normal and pathological human prostate

Rather than mimicking gut hormones to suppress appetite, it stimulates the pituitary gland to produce and release more natural growth hormone

Jain RK