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Clinically, this resistance manifests in two distinct patterns, arising from both the progressive functional exhaustion of tumor-specific T cells and the dynamic equilibrium between immune attack and tumor evasion, which are continuously challenged within an immunosuppressive tumor microenvironment (TME) sculpted by immunoediting

Proteins are very important signposts of cellular redox status and through their structure/function modulation, ROS can also influence gene expression profile by affecting intracellular signal transduction pathways

doi: 10.1016/j.lfs.2020.118598 47 AmayaMLInguvaAPeiSJonesCKrugAYeHet al

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