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Common examples include high blood pressure (hypertension), type 2 diabetes, sleep apnea, or heart disease

2017 Feb;16(1):42-49

Interestingly, corynantheidine, an indole precursor of corynoxine/corynoxine B, was discovered to be a functional -opioid receptor antagonist ( 3.2 Adrenergic Receptors In addition to opioid receptors, the adrenergic neurotransmitter system is another major pharmacological target of kratom in treating pain and opioid withdrawal symptoms