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Staurosporine bolster the mitochondrial ROS production and caspase-3 activityH 2 O 2 and staurosporine increased SOD1 activity slightly and reduced glutathione reductase (Ribeiro et al., 2013)

D.ZhuangS.et al (2019b)

Glossary ACSL4 Acyl-CoA synthetase long chain family member4 ALOXs Arachidonate-lipoxygenase BA Betulinic Acid BBB Blood-brain barrier CA9 Carbonic anhydrase IX CAFs Cancer associated fibroblasts CDKN2A Cyclin-Dependent Kinase Inhibitor 2A CoQ10 Coenzyme Q10 CTL Cytotoxic T Lymphocyte DAMP Damage-associated molecular patterns DC Dendritic Cell DHODH Dihydroorotate Dehydrogenase DMT1 Divalent Metal Transporter 1 ECH1 Enoy-CoA hydratase 1 EMT Epithelial-mesenchymal transition EVs Extracellular Vesicles Fabp7 Fatty Acid Binding Protein 7 FADS2 Fatty acid desaturase 2 FAO Fatty acid oxidation Fer-1 Ferrostatin-1 IFI16 Interferon-inducible protein 16 LLMs Lipid-laden macrophages LPCAT3 Lyso-PL Acyl-transferases 3 MCAD Medium-chain acyl-CoA dehydrogenase MDA Malondialdehyde MDSC Myeloid-derived suppressor cells MGMT O 6-methylguanine-DNA methyltransferase MXRA8 Matrix Remodeling Associated 8 NCOA4 Nuclear Receptor Coactivator 4 NK Natural Killer cells PCD Programmed cell death PD-1 Programmed death 1 PD-L1 Programmed Cell Death Ligand 1 PDT Photodynamic therapy PHD Prolyl Hydroxylase PLA2G7 Lipoprotein-associated phospholipaseA2 ROS Reactive Oxygen Species RSL3 RAS-selective lethal 3 SIRT3 Silent mating type information regulation2 homolog-3 FIN56 Ferroptosis inducer 6 FRG Ferroptosis-Related Genes FSP1 Ferroptosis-suppressor-protein 1 FTH1 Ferritin Heavy Chain FTL Ferritin Light Chain GaM Gallium maltolate GBM Glioblastoma GDEs GBM cell-derived exosome GDF15 Growth Differentiation Factor 15 GGT1 Gamma-Glutamyl Transferase 1 GPX4 Glutathione peroxidase 4 GSC Glioblastoma stem cells GSH Glutathione HFE Homeostatic iron regulator Gene HIF Hypoxia-inducible factor HO-1 Heme oxygenase 1 I3P Indole-3-pyruvic acid ICB Immune checkpoint blockade ICD Immunogenic cell death IDH Isocitrate dehydrogenase IL4I1 Interleukin-4induced 1 protein STAT1 Signal Transducer and Activator of Transcription 1 System Xc Cystine/glutamate antiporter system TAM Tumor-associated macrophage TAN Tumor associated neutrophils TDP-43 TAR DNA binding protein-43 TfR1 Transferrin receptor protein 1 TME Tumor immune microenvironment TMZ Temozolomide TRAF3 TNF receptor associated factor 3 Treg Regulatory T cells VEGFA Vascular endothelial growth factor References 1 SchaffLRMellinghoffIK

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