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Shigematsu H, Hirata T, Nishina M, Yasui D, Ozaki S

For the complete trial timeline, see our Retatrutide Approval Status 2026 guide

In response to restricted MET, folate or one-carbon metabolism in wild-type mice was elevated resulting in increased levels of MET compared to higher MET diets and to MET restriction in dwarf mice

(A ) PLS-DA score plot as multivariate data analyses based on metabolomics data between three tamoxifen-treated groups (each group contains 9 samples) compared to the control group (n = 9)

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