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The resulting bioactive lipid vesicles protect active compounds, enhance bioavailability, accelerate absorption, improve cellular uptake, and support gastrointestinal comfort

While previous reviews have focused on the overall role of ferroptosis in OA or orthopedic diseases, they often lack an in-depth analysis centered on GPX4 as the core inhibitory factor

As pointed out by the legendary immunologist Andrea Ablasser, such a universal sensing mechanism violates one of the most fundamental rules of the classical pattern recognition dogma, which is based on pathogen-specific structural patterns instructing self- versus nonself discrimination (123)