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Functional Overview of CIRS Biomarker Pathways and Molecular Targets of Botanical Extracts CIRS is best conceptualized as a dynamic network disorder, wherein environmental biotoxins interact with host genetic susceptibility to dysregulate immune signaling, endocrine control, and vascular function

Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, et al

Furthermore, mutations in either nuclear or mitochondrial DNA encoding for flavoenzymes and flavin transporters significantly contribute to the development of various neurological disorders

This raises concerns about overreliance on such models for defining CSC identity