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Although the specific biochemical pathways and molecular interactions of this protective mechanism are not fully understood, it is evident that GCH1 plays a significant role in maintaining cellular redox balance and fortifying the cell against oxidative stress (97)

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The long distance from the central metabolism means that only limited flux could be allocated to glutarate under normal conditions

Antonoff MB, Kui N, Sun R, Deboever N, Hofstetter W, Mehran RJ, Morris VK, Rice DC, Swisher SG , Vaporciyan AA, Walsh GL, Rajaram R