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Int J Mol Sci 22(6):3097 Acknowledgements None

Nakahara M

In the pivotal TRIDENT-1 study, Augtyro, a tyrosine kinase inhibitor (TKI) targeting ROS1 oncogenic fusions, led to an objective response rate of 79% in TKI-naive patients

Tannic acid exerts anti-apoptotic activity by down-regulating the caspase-3, Bax, and up-regulating Bcl-2, and activates the antioxidant defense system by up-regulating Nrf2 and HO-1 (Zhang et al., 2017)