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For example, PLP is required for the synthesis of neurotransmitters such as GABA and serotonin, for heme biosynthesis (through -amino levulinate synthase in red blood cell production), and for amino acid transformations

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Whether those studies establish a sufficient benefit-risk profile for human use through compounding pharmacies was the core scientific question, and the committee's majority answered yes over the objections of FDA scientists who answered no

Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay: Miniperspective