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The findings underscore the importance of GSH and NADPH production in dealing with oxidative stress during retinal development, especially after peak rod degeneration occurs in RP, leading to increased oxygen tension

However, due to its strong oxidizing properties, prolonged exposure to high doses of ozone can cause burns and even carcinogenic effects when in contact with skin and mucous membranes (30)

Increased toxicity is noted to occur in poor metabolizers with several psychotropics such as desipramine, haloperidol, amitriptyline and venlafaxine with CYP2D6 variants influencing analgesic response to opioids such as codeine 8

La forme libre (non lie d'autres molcules) est celle qui est utilise dans les essais cliniques et qui bnficie du recul le plus solide