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These may range from relatively minor issues like acne, oily skin, and hair loss to more serious concerns such as [36]: Gynecomastia (aromatizable/non-5-reduced AAS) [37] Liver damage (oral AAS) [38, 39, 40, 41, 42, 43, 44] Cardiovascular complications (due to unfavorable effects on cholesterol levels, especially with AAS such as trenbolone) [45] Psychological changes [10] Disruption in the body's natural production of hormones, leading to infertility [46] For example, oral AAS that have been reported to induce serious and even life-threatening liver injury include Winstrol (stanozolol, Stromba), Superdrol (methasterone), Dianabol (methandienone), Metandren (methyltestosterone), and others [38, 39, 40, 41, 42, 43, 44]

Song et al., 2022)

It is generally well-tolerated

CAT is known to have a significant role in the development of tolerance to oxidative stress in cells, 24, 25 particularly when there is decreased GPx activity 18 or elevated H 2 O 2 levels