glutathione synthesis ppt The cycle: Glutathione metabolism beyond the γ‐glutamyl cycle - Bachhawat - 2018 - IUBMB Life Glutathione synthesis. GSH synthesis relies

These findings suggest that enhanced lipid peroxidation was not driven by induction of the ACSL4/LPCAT3 or by downregulation of GPX4 expression or intrinsic activity, but rather that the depletion of GSH was the primary cause

In vitro, astrocytes derived from induced pluripotent stem cells obtained from patients with FTD-MAPT showed hypertrophy, elevated GFAP protein levels, disease-associated changes in TAU expression, increased vulnerability to oxidative stress, and protein ubiquitination 231

10.1073/pnas.0911175107 76 HoehleS

The newly torn diseased lumen is called the false lumen and the original lumen with normal blood flow is called the true lumen