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The serious adverse events documented in HPS2-THRIVE (increased diabetes, infections, gastrointestinal problems, bleeding, and musculoskeletal complications) make high-dose nicotinic acid a risk that is difficult to justify without a clear clinical indication

Luo P, Chen T, Zhao Y, Zhang L, Yang Y, Liu W, et al

[6] Oral Dosing Guide Larazotide is an oral, luminally-acting peptide, so its dosing is a record of what appeared in the trials rather than a titration schedule and its most striking feature is an inverted dose-response, where the lowest maintenance dose is the one that worked

Slides were cooled to RT and subsequently blocked with PBS + 3%BSA for 1 h at RT