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Our previous findings of elevated levels of L-DOPA and its metabolite 3- O -methyldopa in several grey matter brain regions in the same LID animals, along with increased dopamine and metabolite levels, support the hypothesis that cellular membrane permeability may differ significantly between LID and non-LID animals 35 Such differences may contribute to the altered L-DOPA levels, potentially due to blood-brain barrier impairment or L-DOPA efflux in non-LID animals, leading to dyskinesia

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This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction

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