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doi: 10.2174/1874285801812010230 39 DaoudZ.SuraM.Abdel-MassihR

This ghrelin-like activity contributes to several secondary effects that go beyond hypertrophy and fat loss : Neuroprotection and brain health , including memory and neural regeneration Mood enhancement and cognitive support , linked to ghrelins interaction with dopamine and serotonin systems Increased appetite , which can support bulking or be managed during a cut Improved sleep architecture , especially deep REM phases MK-677 improved REM sleep patterns in healthy men, suggesting beneficial effects on recovery, memory, and hormonal balance. Copinschi et al., The Journal of Clinical Endocrinology & Metabolism MK-677 also crosses the blood-brain barrier , functioning like a neuropeptide within the central nervous system

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57,76 Moreover, in certain cell types, NADPH oxidase may translocate to the mitochondria, further exacerbating oxidative stress