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These findings suggest that loss of PDI functional activity can directly lead to apoptosis, or indirectly, to a range of cellular abnormalities, such as oxidative stress, protein misfolding, as well as cell death (Jeon et al., 2014)

Most patients exhibit good long-term tolerance to these herbs and rarely develop drug resistance or dependence

NADPH: reduced nicotinamide adenin dinucleotide phosphate

As shown in Figure 7 , the studies suggest that BHB or BHB-induced PTMs may play an important role in the pathogenesis and treatment of metabolic diseases and in metabolic reprogramming