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For instance, TNF, primarily generated by activated macrophages, has the potential to increase ROS production in lung epithelial cells, which is a plausible mechanism for inflammation-induced carcinogenesis [41]

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108 The oral administration of aqueous extract of Jamun stem bark at doses of 300, 2,000, or 5,000 mg/kg body weight in rats was safe up to 5 g/kg body weight, and repeated oral administration of 300, 1,000, or 2,000 mg/kg body weight of aqueous extract of Jamun stem bark for 28 days did not produce any toxicity in the rats

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