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However, it is important to keep in mind that CLE visualizes a basolateral (subepithelial) to apical (luminal) flux of a small molecule (fluorescein) of which the correlation to luminal to subepithelial passage of luminal compounds, which is hypothesized to trigger a mucosal immune response and symptoms, is still unclear

10.1002/ctm2.778 136 LiuS.-J.ZhaoQ.PengC.MaoQ.WuF.ZhangF.-H.et al (2021)

The lipid-clearing effects of the glucagon analogue were independent of the PDE4/cAMP/PKA axis that governed energy expenditure, meaning the fat-lowering and calorie-burning arms of glucagon action are at least partly separable at the molecular level