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Indeed, it is known that the enzyme -glutamyltranspeptidase (GGT) on the external cell membrane initiates this process (called the -glutamyl cycle) [12, 50, 51]

Arterial chemotherapy of oxaliplatin plus fluorouracil versus Sorafenib in advanced hepatocellular carcinoma: A biomolecular Exploratory, Randomized, phase III trial (FOHAIC-1)

On the other hand, free radicals directly degrade the joint cartilage by targeting its proteoglycan and restricting its synthesis

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