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CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury After Focal Cerebral Ischemia

It participates in methyl transfer and folate metabolism in the body, and promotes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate

This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors