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Neuroinflammation 16 , 196 (2019)

They upregulate the expression of Bcl-2 and downregulate the expression of CPP32 and ICH-1L, thereby inhibiting apoptosis induced by anti-Fas monoclonal antibodies

(ii) large-scale silencing approaches and functional screenings, determining whether the genetic or pharmacological inhibition of specific proteins alters CDDP sensitivity (in preclinical models only) and (iii) multiplex genotyping studies, assessing in a high-throughput manner whether particular (combinations of) single-nucleotide polymorphisms (SNPs) are associated with increased or reduced CDDP sensitivity (in clinical settings)

NAD + is not required but substantially enhances the ROS production [51]