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However, this combination appears to have no effect on clinical outcomes ( Future research directions and unresolved questions Despite the increasing body of evidence supporting the role of CoQ10 in enhancing female fertility, several critical gaps and future research directions must be emphasized to facilitate its clinical translation

Long-term outcomes (cardiovascular events, incident diabetes, all-cause mortality) are accessible only through observational cohort studies with follow-up periods of 1030 years (97, 98), and the inability to reconcile short-term RCT mechanistic data with long-term observational associations represents a fundamental epistemic gap in this field