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Description

The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides

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Oxidative damage, mitochondrial dysfunction, and altered energy metabolism are directly implicated in the development of cisplatin-induced neurotoxicity (Maccio and Madeddu 2013)

This is achieved through the induction of endothelial expression of Major Facilitator Superfamily Domain-containing 2a (Mfsd2a), which is a transporter of docosahexaenoic acid (DHA) (Nguyen et al., 2014)