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The scientists commented that: regulation of the pro-inflammatory milieu of the ischemic retina can be enhanced by ARA290 and may be a useful [research agent] to ECFC-based cell [procedures] for ischemic retinopathies

It may possibly reflect differences in the occupancy of the hydrophobic pocket in VP1, or at another site affecting stability, since the ternary complexes of PV3-SC8 GPP3+GSH and PV3-SC8 pleconaril+GSH demonstrate that the bound factors could act additively or synergistically