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Different types of cell deaths were also verified using various inhibitors on the cells treated with GOx/CuSAE, including apoptosis inhibitor (Z-VAD-fmk), necrosis inhibitor (necrostatin-1, nec-1), autophagy inhibitor (chloroquine, CQ), and ferroptosis inhibitor (deferoxamine, DFO) 34,35,36

Even tiny amounts of condensation can initiate hydrolysis, breaking down the peptide bonds