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SKU: 543551208
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Description

Lactate induces the stemness potentials of detached breast cancer cells by promoting -KG-DNMT3B-mediated hypomethylation of SOX2 To clarify the metabolic-epigenetic mechanism of lactate-induced stemness potentials in detached breast cancer cells via fueling the TCA cycle, we next focused on -ketoglutarate (-KG), a vital signaling molecule regulating stemness gene expression and one of the top three significantly increased TCA cycle intermediates (oxaloacetate, succinate, -KG) in 13 C 3 -lactate treated AR cells (Fig