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Pathology of retinal pigment epithelium during age-related macular degeneration The RPE, a single layer of polarized cells that is situated between the rods and cones and the choriocapillaris in the outermost portion of the retina, undergoes major pathological changes during AMD progression (24, 25) (Figure 1)

Thus, the excess PyroGlu in a septic patient without an enzymatic deficit in the gamma-glutamyl cycle could be associated with GSH depletion, and therefore excessive oxidative stress and its negative consequences

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Dual role of ROS as signal and stress agents: iron tips the balance in favor of toxic effects