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The inverse variance weighted method was conducted to assess the primary outcomes, and multivariate MR analyses were performed to combine estimates of the causal effects of multiple risk factors

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Oxidative stress is caused by a variety of environmental and dietary factors such as consumption of bad oils, psychological stress, environmental toxins (think mold, air pollution, pesticides), and others

Besides the control that mTORC1 exerts on TFEB and TFE3 recruitment, a recent work has reported a feedback circuit wherein these transcription factors can control lysosomal recruitment of mTORC1 by regulating the expression of RagD [158]