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Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo

Seco-sterols such as 3hydroxy-5-oxo-5,6-secocholestan-6-al and its stable aldolization product, the main ozonolysis metabolites derived from cholesterol, have been detected in brain samples of patients who have died from Alzheimer's disease and Lewy body dementia, and they have been found in atherosclerotic lesions

Using RT, we were able to monitor the dynamic changes of GSH in living cells, which subsequently led to the observation of enhanced antioxidant capability of activated neurons and time-dependent changes of GSH during the ferroptosis process