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Milestones in LPA discovery and research LPA was initially regarded as a minor phospholipid intermediate, but over the past five decades, it has emerged as a central signaling molecule with broad physiological and pathological relevance

Scientific interest in these compounds focuses on understanding their biological activity, molecular signalling, cellular responses, and interactions with physiological pathways involved in tissue biology

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Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase