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Carnitine plays a key role in muscle energy metabolism, and its deficiency can lead to ATP depletion and impaired calcium reuptake in skeletal muscle, promoting sustained contraction and cramping

53,54 In a 10-year prospective study by Criqui et al, 10 PAD patients with and without a history of cardiovascular disease had a significantly increased risk of dying of any cause or as a result of cardiovascular disease or CAD than age-matched controls

Results The initial search retrieved 1024 articles, and a total of 11 studies were finally included after applying inclusion and exclusion criteria

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