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Permanent paralysis occurs due to severe damage or injury to the facial nerve and may last for years or a lifetime

If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every three to four days for another two to three weeks

Renal dosing adjustments for adult patients with HABP/VABP per estimated CrCl (mL/min) a,b a,b 30 to 50 CrCl (mL/min) 1.5 g (1 g and 0.5 g) intravenously every 8 hours 15 to 29 CrCl (mL/min) 750 mg (500 mg and 250 mg) intravenously every 8 hours For patients with end-stage renal disease on hemodialysis: a single loading dose of 2.25 g (1.5 g and 0.75 g) followed by a 450-mg (300 mg and 150 mg) maintenance dose administered intravenously every 8 hours for the remainder of the treatment period (on hemodialysis days, administer the dose at the earliest possible time following completion of dialysis)

After a short visit of 40 min