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This paper presents, for the first time to the authors knowledge, an untargeted metabolomics study of the polar metabolome of untreated MDA-MB-231 parental (cDDP-sensitive) cells and derived MDA-MB-231/R cells (cDDP-resistant), the latter having been previously established as a model of acquired cDDP-resistance [30]

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Moreover, a growing body of evidence suggests that p53 regulates ferroptosis either by transcriptional or posttranslational mechanisms such as modulating the downstream expression of SLC7A11 , 239 SAT1 (encoding spermidine/spermine N1-acetyltransferase 1), 240 GLS2 (encoding glutaminase 2), 25 and CDKN1A/p21 (encoding cyclin dependent kinase inhibitor 1A), 241 or by directly inhibiting DPP4 activity in colorectal cancer cells

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Lpez-Blanch R, Salvador-Palmer R, Oriol-Caballo M, Moreno-Murciano P, Dellinger RW, Estrela JM, et al

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