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Nature 477 (7364), 349353 (2011) B

Research applications In-vitro modeling of synergistic GHRH/GHRP receptor cross-talk Pre-clinical study of pulsatile GH-secretagogue dynamics Comparative receptor-pathway research (cAMP vs calcium convergence) Reference standard for analytical characterization of blended preparations Key facts Combines a GHRH-receptor analog with a selective GHS-R1a agonist Nominal 5mg + 5mg per-component loading per vial Components act through mechanistically independent, convergent pathways Supplied as a co-lyophilized research powder for in-vitro use Product specifications Class: GHRH analog + GHRP/ghrelin-receptor agonist research blend Also known as: Mod-GRF + Ipamorelin blend Form: Lyophilized powder vial Purity: 99% (HPLC verified) Testing: Independent third-party HPLC + mass spectrometry Documentation: Certificate of analysis per batch Storage: Store lyophilized at -20C

Indeed, the mechanisms involved in E2-mediated proliferation are associated with the inhibition of the tumor suppressor protein, p53, which, in turn, generates the downstream activation of cyclin-dependent kinases (CDKs) and, consequently, the release of the retinoblastoma protein (Rb) that promote the progression of the cell cycle by activating diverse transcription factors (Gompel et al., 2004)

thaliana (Parisy et al., 2007)