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The copy number variant of the HBD2 gene variant DFEB4 and circulating protein concentrations have been investigated in stroke patients (Tiszlavicz et al., 2012)

Regarding papaverine, a direct-acting vasodilator, when injected intraperitoneally in noise-exposed Wistar rats significantly decreases the apoptotic death of hair cells resulting in significantly smaller threshold shifts when compared to noise-exposed untreated animals (Kum et al., 2018)

Increased testosterone provides a negative feedback to the hypothalamus and pituitary, leading to reductions in both GnRH pulse frequency and pituitary responsiveness to GnRH, ultimately resulting in reduced gonadotropin release [37]

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