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Across multiple experimental modelsincluding Parkinsons disease, Alzheimers disease, and cerebral ischemia-reperfusion injuryriboflavin supplementation has demonstrated consistent neuroprotective effects, reflected in reduced oxidative burden and preservation of neuronal integrity (34)

In the pig LR3 IGF-1 study, plasma endogenous IGF-1 was suppressed during infusion (Tomas et al., 1997), and the guinea pig study showed reduced plasma IGF-I and IGF-II during LR3 administration (Bastian et al., 1995)