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This type of lesion is directly repaired by a suicide enzyme known as MGMT, which removes the methyl group of the DNA base and transfers it to its cysteine residue

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus

Discussion Radiogenomics in hematologic malignancies The rule is, not to besiege walled cities if it can possibly be avoided - The Art of War , Sun Tzu While successful efforts in non-hematologic malignancies have linked radiation sensitivity to genomic classifiers for solid tumors, implicating genes like KEAP1 and CTNNB1 and pathways such as ROS reduction and cell-cycle deregulation, these studies have often explicitly omitted hematologic malignancies (162)

Intracellular LPO generation BODIPY581/591-C11 (Thermo Fisher), a fluorescent probe for LPO detection that can insert into lipid membranes and been oxidized by intracellular LPO, was used to assess the intracellular LPO level