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The heterogeneity in tissue oxygen pressures between physiologically different compartments has become central to heated debates, ultimately resulting in the new definition of a more physiological concept related to hypoxia, termed dysoxia. Dysoxia is a condition of hypoxia wherein the oxygen availability at the cellular level is inadequate to sustain enough oxidative phosphorylation to form ATP [15,16,17]

However, these measurements dont always correlate perfectly with tissue levels or functional status

Found in human plasma, saliva, and urine, its levels decline significantly with age, coinciding with reduced tissue repair capacity

Table 4 Commonly used engineered E