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34 There is no robust evidence supporting their use in the very small number of studies that have been published

There was no significant difference in heart weight/tibia length (HW/TL) between control and KO mice, indicating that SIRT5 KO did not cause spontaneous cardiac hypertrophy, whereas DCM modeling significantly increased HW/TL values and SIRT5 KO mice demonstrated more severe cardiac hypertrophy (Fig