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Less well known clinical manifestations of iron deficiency include neurotic reactions and neurasthenia, decreased muscle performance and general exercise tolerance, and disturbances in myocardial metabolic processes, peripheral circulation (decreased peripheral resistance and venous tone, decreased functional reserves of arterioles), and microcirculation

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Cytotoxicity assays, including MTT and SRB, showed significantly reduced toxicity for the PEGylated nanoparticle formulation compared to free tolcapone (cell viability exceeded 85% at 10, 25, and 50 M of the formula after 24 and 48 h of treatment)