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LDN works primarily by temporarily blocking opioid receptors, specifically the OGF-OGFr axis, which plays a role in the release of endorphins and enkephalins

Furthermore, in an intracerebral hemorrhage (ICH) model, neural stem cell secretions inhibited hemin-induced ferroptosis and cerebral edema via the Nrf2 pathway, with the key component HSPE1 protein potentially mediating this protective effect [133]

H., Herianto, S., Lee, C

Acknowledgements The authors appreciate and thank the efforts of the Center for the Development of Clinical Researches of the Educational and Therapeutic Research Complex of Birjand University of Medical Sciences