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Thus, it is evident that the increaseof MDR1/ Pgp activity resulting from the action of different inducers is dependent on the particular conditions (evidently on the activation of certain signaling pathways in the cell)

Similarly, in hepatocytes exposed to lipotoxic stressors, zinc supplementation reduces cytotoxicity by mitigating ER stress and enhancing antioxidant defense, demonstrating its capacity to preserve proteostasis and limit inflammatory responses 178

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[6] [15] Isomerism Carotenoids contain many double bonds that can exhibit cistrans isomerism, also known as geometric isomerism