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10.1016/j.cell.2014.04.046 164 TalekarM.OuyangQ.GoldbergM

198 Several pathways have been implicated in micropinocytosis events, such as the ERK/MAPK pathway activated by oncogenic RAS, and PI3K/mTOR signalling pathways

In related experiments, overexpression of PTP1B in HEK 293T cells inhibited ARE-mediated luciferase expression after treatment with APAP for 16 h (Figure 4e), reinforcing the involvement of PTP1B in Nrf2-mediated antioxidant response to APAP

However, using recognizable spectrophotometric features that are indicative of the catalytic sequence, most particularly three charge transfer absorption transitions, permits assignment of the order of specific common catalytic events that in turn has indicated function for four of the five variants studied