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Description

Deletion of Carboxypeptidase E in beta-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Inhibition of PDE4 impairs cAMP degradation, resulting in increased intracellular cAMP levels, which subsequently activate protein kinase A (PKA) and attenuate pro-inflammatory signaling pathways, such as NF-B and mitogen-activated protein kinases (MAPKs)