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Moreover, animal experiments allow researchers to investigate the interactions between apical lesions and systemic conditions, such as cardiovascular diseases (Brilhante Wolle et al., 2012) and diabetes (Prieto et al., 2017)

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Journal of the National Cancer Institute, 83 (6), 437-441

There were several flaws in these studies such as being-underpowered or not having well-designed (Kenefick et al., 2002