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The intestinal epithelial monolayer is composed of different types of specialized epithelial cells, such as enterocytes, Paneth cells, goblet cells, endocytes, and microfold cells, each with a distinct function

doi: 10.18632/aging.103435 207 YangM.FukuiH.EdaH.XuX.KitayamaY.HaraK.et al

This antioxidant activity is vital because excessive ROS can impair mitochondrial function, leading to oxidative stress and affecting the energy production of neurons and glial cells, potentially causing migraine headaches ( Vitamin B2 deficiency disrupts intermediary metabolism, potentially impairing energy production via the ETC, which is mainly concerned for the nervous system, given its high energy demands, and also can lead to disorders, such as migraine, because of energy failure, alongside overproduction of ROS (47)

tract and in the bloodstream, thus supplemental sources have been difficult