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Similarly, oxaliplatin triggered the activation of cutaneous mast cells (another type of tissue-resident immune cells) via the activation of proteinase-activated receptor 2 (PAR2), and induced IENF degeneration and mechanical allodynia

The enzyme nitric oxide synthase (NOS) is responsible for the production of nitric oxide (NO), a reactive nitrogen species [49]

Additionally, the exposed group demonstrated significantly higher PLA 2 and SMase enzyme activity, with their median values being 518 and 706 AFU/mg, compared to 267 and 444 AFU/mg in the unexposed workers