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Clinical: Trials in human subjects for safety and efficacy evaluation

This hormone travels to the pituitary gland and signals the release of growth hormone

PMID 7642582

FIGURE 1 The Discovery of ACO and Its Reaction Mechanism For a long time it remained extremely difficult to purify ACO (formerly named the Ethylene Forming Enzyme, EFE) and determine its in vitro activity, mainly because it was thought that ACO was a membrane bound protein that lost its activity upon homogenization ( in vitro ACO activity was retained in membrane preparations of pea (Porter et al., 1986), bean (Mayne and Kende, 1986), Sprengers asparagus (Porter et al., 1986) and kiwi fruit (Mitchell et al., 1988), which was only a fraction (50.5%) of the total in vivo ethylene production capacity